| Identification | Back Directory | [Name]
LY3154885 | [CAS]
2379422-72-5 | [Synonyms]
LY3154885
2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(1-methyl-4-pyrazolyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
Ethanone, 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3,4-dihydro-3-(hydroxymethyl)-1-methyl-5-(1-methyl-1H-pyrazol-4-yl)-2(1H)-isoquinolinyl]- | [Molecular Formula]
C23H23Cl2N3O2 | [MOL File]
2379422-72-5.mol | [Molecular Weight]
444.35 |
| Hazard Information | Back Directory | [Uses]
LY3154885 is an orally active dopamine D1 receptor positive allosteric modulator (PAM). LY3154885 has an improved agent-agent interactions (DDI) risk profile[1]. | [References]
[1] Junliang Hao, et al. Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile. J Med Chem. 2022 Mar 10;65(5):3786-3797. DOI:10.1021/acs.jmedchem.1c01887 |
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