| Identification | Back Directory | [Name]
Acetic acid, 2-[[1-(2-chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy]- | [CAS]
2375196-30-6 | [Synonyms]
2-((1-(2-Chloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl)oxy)acetic acid
Acetic acid, 2-[[1-(2-chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy]- | [Molecular Formula]
C13H14ClNO4 | [MOL File]
2375196-30-6.mol | [Molecular Weight]
283.71 |
| Chemical Properties | Back Directory | [Boiling point ]
573.3±50.0 °C(Predicted) | [density ]
1.383±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 66.67 mg/mL (234.99 mM) | [form ]
Solid | [pka]
3.20±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
KB02-COOH is a fragment of synthesis of ubiquitin E3 ligase ligand KB02. KB02 can be used in the synthesis of PROTAC, such as KB02-JQ1 and KB02-SLF [1]. | [References]
[1]. Zhang X, et al. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746. |
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