| Identification | Back Directory | [Name]
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- | [CAS]
2369979-68-8 | [Synonyms]
8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro-5H-Dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- | [Molecular Formula]
C19H20ClFN4 | [MDL Number]
MFCD34167517 | [MOL File]
2369979-68-8.mol | [Molecular Weight]
358.84 |
| Chemical Properties | Back Directory | [Boiling point ]
493.0±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO|17.94|50| | [form ]
solid | [pka]
7.63±0.10(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Biological Activity]
JHU37160 (J60) is a potent DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) ligand (hM3Dq/hM4Di Ki = 1.9/3.6 nM using mouse brain tissue18.5/0.2 nM by celluar BRET assays) with ~25-fold improved affinity than C21 and high in vivo potency for CNS applications. J60 selectively competes against clozapine at DREADDsbut not other clozapine-binding sites in mouse brain tissue ex vivo (10 nM)increases hM3Dq-stimulated locomotion in TH-hM3Dq rats (0.01-0.3 mg/kg i.p.) and selectively inhibits locomotor activity of D1-hM3Dq and D1-hM4Di transgenicbut not wild-typemice (0.01-1 mg/kg i.p.). | [storage]
Room temperature |
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DC Chemicals
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http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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