| Chemical Properties | Back Directory | [Boiling point ]
573.1±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (616.58 mM; Need ultrasonic) | [form ]
Solid | [pka]
15.29±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CWHM-1008 is a potent and orally active antimalarial agent, with EC50 values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively[1]. | [IC 50]
Plasmodium | [References]
[1] Meyers MJ, et al. 4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides. J Med Chem. 2019 Mar 22. DOI:10.1021/acs.jmedchem.8b01972 |
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