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ChemicalBook--->CAS DataBase List--->23602-78-0

23602-78-0

23602-78-0 Structure

23602-78-0 Structure
IdentificationBack Directory
[Name]

BENFLUOREX HYDROCHLORIDE
[CAS]

23602-78-0
[Synonyms]

s992
s780
S-780
se780
jp992
SE-780
D07192
Minolip
Mediaxal
BENFLUREX
BRN 4152887
benfluramate
Mediaxal (tn)
Benfluorex - API
Benfluorex (inn/ban)
Benzoyloxyfenfluramine
N-(2-Benzoyloxyethyl)norfenfluramine
Benfluorex (base and/or unspecified salts)
1-(m-Trifluoromethylphenyl)-2-(benzoyloxy)ethylaminopropane
2-(alpha-methyl-m-trifluoromethylphenethylamino)-ethanobenzoate
2-(alpha-methyl-m-trifluoromethylphenethylamino)ethanolbenzoate
2-(alpha-Methyl-m-trifluoromethylphenethylamino)ethanol benzoate
Ethanol, 2-(alpha-methyl-m-trifluoromethylphenethylamino)-, benzoate
2-((1-Methyl-2-[3-(trifluoromethyl)phenyl]ethyl)amino)ethyl benzoate
Benzoic acid 2-[(α-methyl-3-trifluoromethylphenethyl)amino]ethyl ester
n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-phenethylaminbenzoate
n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylaminebenzoate
N-(2-Hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylamine benzoate
benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester
Ethanol, 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, benzoate
n-(1-methyl-2-(3-[trifluoromethyl]-phenyl)ethyl]aminoethanol benzoate ester
Ethanol, 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, 1-benzoate
2-[[alpha-Methyl-m-(trifluoromethyl)phenethyl]amino]ethanol benzoate (ester)
Phenethylamine, N-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-, benzoate
Benzoic acid 2-[[1-methyl-2-(3-trifluoromethylphenyl)ethyl]amino]ethyl ester
[EINECS(EC#)]

245-777-9
[Molecular Formula]

C19H20F3NO2
[MDL Number]

MFCD00242709
[MOL File]

23602-78-0.mol
[Molecular Weight]

351.36
Chemical PropertiesBack Directory
[Boiling point ]

420.5±45.0 °C(Predicted)
[density ]

1.183±0.06 g/cm3(Predicted)
[pka]

8.23±0.10(Predicted)
Safety DataBack Directory
[WGK Germany ]

2
[RTECS ]

KL8275000
[Toxicity]

LD50 oral in mouse: 2300mg/kg
Hazard InformationBack Directory
[Originator]

Mediator,Servier,France,1976
[Uses]

antihyperlipoproteinemic
[Definition]

ChEBI:Benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester is a benzoate ester.
[Manufacturing Process]

To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β- hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were added successively 15 parts of 4.7N hydrochloric ether and a solution of 14 parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from 230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)- 2-(β-benzoyloxyethyl)amino propane hydrochloride melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts ether are added, then 10 parts of a concentrated solution of ammonium hydroxide. The mixture is stirred a few minutes until the salt is dissolved, then the ethered solution is poured off and dried. After the ether is eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β- benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.
[Therapeutic Function]

Antihyperlipidemic, Cardiovascular
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