| Chemical Properties | Back Directory | [Boiling point ]
463.0±30.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [form ]
Oil | [pka]
12.75±0.46(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Biological Activity]
AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 [1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1. |
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