| Identification | Back Directory | [Name]
BMS-470539 dihydrochloride | [CAS]
2341796-82-3 | [Synonyms]
BMS470539 dihydrochloride,BMS 470539 dihydrochloride
BMS-470539 dihydrochloride, BMS 470539 dihydrochloride, BMS470539 dihydrochloride, BMS 470539 HCl | [Molecular Formula]
C32H42ClN5O4 | [MOL File]
2341796-82-3.mol | [Molecular Weight]
596.17 |
| Chemical Properties | Back Directory | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO:63.26(Max Conc. mg/mL);100.0(Max Conc. mM)
Water:63.26(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white | [Water Solubility ]
H2O: 2mg/mL, clear (Warmed) |
| Hazard Information | Back Directory | [Biological Activity]
BMS-470539 is a highly potent and selective melanocortin-1 receptor (MC-1R; MC1R) agonist (AMP stimulation EC50 = 11.6/16.2/16.8 nM using B16/HBL/CHO-MC1R; little or no potency toward MC2RMC3R MC4R MC5R) with anti-inflammatory efficacy in mice in vivo (15-100 μmol/kg via i.v. or s.c. 0.5-1 h prior to 1 μg LPS s.c.). |
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