| Identification | Back Directory | [Name]
BAY-885 | [CAS]
2307249-33-6 | [Synonyms]
BAY-885
BAY-885 USP/EP/BP
[2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone
Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]- | [Molecular Formula]
C25H28F3N7O2 | [MDL Number]
MFCD32067879 | [MOL File]
2307249-33-6.mol | [Molecular Weight]
515.53 |
| Questions And Answer | Back Directory | [Use]
BAY-885 is a highly potent and selective ERK5 inhibitor. | [In vitro]
BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation. |
| Chemical Properties | Back Directory | [Boiling point ]
685.0±55.0 °C(Predicted) | [density ]
1.362±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO:23.33(Max Conc. mg/mL);45.25(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);15.52(Max Conc. mM) | [form ]
A solid | [pka]
7.06±0.42(Predicted) | [color ]
White to light yellow |
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| Company Name: |
Syntechem Co.,Ltd.
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| Tel: |
519-88298820 15861130028 |
| Website: |
http://www.syntechem.com |
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