| Identification | Back Directory | [Name]
1-Piperazinepropanamide, N-[3,4-dihydro-3-[[4-hydroxy-1-[(3R)-1-oxo-3-phenylbutyl]-4-piperidinyl]methyl]-4-oxo-7-quinazolinyl]-4-methyl- | [CAS]
2305045-76-3 | [Synonyms]
1-Piperazinepropanamide, N-[3,4-dihydro-3-[[4-hydroxy-1-[(3R)-1-oxo-3-phenylbutyl]-4-piperidinyl]methyl]-4-oxo-7-quinazolinyl]-4-methyl- | [Molecular Formula]
C32H42N6O4 | [MOL File]
2305045-76-3.mol | [Molecular Weight]
574.71 |
| Chemical Properties | Back Directory | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
13.61±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
XL188 is a highly selective and potent (IC50 90 nM) non covalent inhibitor of USP7 th at binds to the USP7 active site. XL188 facilitates degradation of HDM2and increases the levels of p53 and p21 in MCF7 cells. |
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