| Identification | Back Directory | [Name]
ADH 1 | [CAS]
229971-81-7 | [Synonyms]
ADH 1
Exherin
CS-2142
Exherin TFA
ADH-1 Exherin
Exherin (ADH-1)
L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-, cyclic (1→5)-disulfide | [Molecular Formula]
C22H34N8O6S2 | [MDL Number]
MFCD18251730 | [MOL File]
229971-81-7.mol | [Molecular Weight]
570.69 |
| Chemical Properties | Back Directory | [Boiling point ]
1183.4±65.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO:2.2(Max Conc. mg/mL);3.86(Max Conc. mM) | [form ]
A solid | [pka]
13.13±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
ADH-1 is an N-cadherin (CD325; NCAD) antagonist th at selectively inhibits NCAD-dependent neurite outgrowth (IC50 = 323 μM; PN1-2 r at cerebral neurons on monolayer of chick NCAD-expressing 3T3)while exhibiting no effect against integrin receptor-dependent neurite outgrowth. ADH-1 inhibits NCAD-mediated signaling events in cultures (0.2-2.5 mg/mL) and exhibits anti-tumor efficacy in vivo (50-100 mg/kg i.p. in rats and mice). |
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