| Identification | Back Directory | [Name]
Fmoc-NH-PEG11-CH2CH2COOH | [CAS]
2291257-76-4 | [Synonyms]
Fmoc-PEG11-acetic acid
Fmoc-NH-PEG11-CH2CH2COOH | [Molecular Formula]
C41H63NO16 | [MDL Number]
MFCD30723256 | [MOL File]
2291257-76-4.mol | [Molecular Weight]
825.95 |
| Chemical Properties | Back Directory | [Boiling point ]
863.2±65.0 °C(Predicted) | [density ]
1.182±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
3.39±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
Fmoc-NH-PEG12-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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