| Identification | Back Directory | [Name]
Fluorinated VHL spy molecule 3 | [CAS]
2290526-29-1 | [Synonyms]
Fluorinated VHL spy molecule 3
(2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide
2-Pyrrolidinecarboxamide, 4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-1-(2,2,2-trifluoroacetyl)-, (2S,4R)-
(2S,4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C18H18F3N3O3S | [MOL File]
2290526-29-1.mol | [Molecular Weight]
413.41 |
| Hazard Information | Back Directory | [Uses]
Fluorinated VHL Spy Molecule 3 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909416, 909432, and 909459.
The E3 ligase VHL is of growing interest for targeted protein degradation, and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders. |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
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http://www.sigmaaldrich.cn |
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