| Identification | Back Directory | [Name]
AMINO[(3,4-DICHLOROBENZYL)SULFANYL]METHANIMINIUM CHLORIDE | [CAS]
22816-60-0 | [Synonyms]
A22 hydrochloride
MreB Perturbing Compound A22
A22 hydrochloride >=95% (HPLC)
2-(3,4-Dichloro-benzyl)-isothiourea
MreB Perturbing Compound A22 hydrochloride
2-(3,4-Dichlorobenzyl)isothiouronium chloride
S-(3,4-Dichlorobenzyl)isothiourea hydrochloride
2-(3,4-Dichloro-benzyl)-isothiourea hydrochloride
AMINO[(3,4-DICHLOROBENZYL)SULFANYL]METHANIMINIUM CHLORIDE
MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem
2-(3,4-dichlorophenyl)methylcarbamimidothioate hydrochloride
[AMINO[(3,4-DICHLOROBENZYL)THIO]METHYLIDENE]AMMONIUM CHLORIDE
Carbamimidothioic acid,(3,4-dichlorophenyl)methyl ester, hydrochloride (1:1) | [Molecular Formula]
C8H9Cl3N2S | [MDL Number]
MFCD00035050 | [MOL File]
22816-60-0.mol | [Molecular Weight]
271.59 |
| Chemical Properties | Back Directory | [Melting point ]
210 °C | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble2mg/mL (clear solution, warmed) | [form ]
White solid | [color ]
white to beige | [Water Solubility ]
water: 2mg/mL
DMSO: 200mg/mL |
| Hazard Information | Back Directory | [Uses]
MreB Perturbing Compound A22 is an isothiourea that reversibly perturbs MreB function. | [Biochem/physiol Actions]
A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria. |
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