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Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid.1 It binds to glucocorticoid receptors in a cell-free assay (IC50 = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 μg/ml.1,2 Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice.1 Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions. | [References]
1.Ueno, H., Maruyama, A., Miyake, M., et al.Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 α-esters containing a functional groupJ. Med. Chem.34(8)2468-2473(1991)
2.Ponec, M., de Haas, C., Bachra, B.N., et al.Effects of glucocorticosteroids on primary human skin fibroblasts. I. Inhibition of the proliferation of cultured primary human skin and mouse L929 fibroblastsArch. Dermatol. Res.259(12)117-123(1977)
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