| Identification | Back Directory | [Name]
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione | [CAS]
227088-94-0 | [Synonyms]
AZ11645373
3-[1-[[(3'-NITRO[1
4-THIAZOLIDINEDIONE
1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione | [Molecular Formula]
C24H21N3O5S | [MDL Number]
MFCD11045276 | [MOL File]
227088-94-0.mol | [Molecular Weight]
463.512 |
| Hazard Information | Back Directory | [Uses]
A selective P2X7 receptor antagonist. | [Biological Activity]
Potent and selective human P2X 7 antagonist (K B values are 5 - 7 and > 10,000 nM at hP2X 7 and rP2X 7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1 β release in vitro (K B values are 15 and 92 nM respectively). | [storage]
Store at +4°C | [References]
1. stokes l, jiang lh, alcaraz l, et al. characterization of a selective and potent antagonist of human p2x(7) receptors, az11645373. british journal of pharmacology. 2006;149(7):880-887. |
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