| Identification | Back Directory | [Name]
Boc-aminooxy-amide-PEG4-propargyl | [CAS]
2253965-01-2 | [Synonyms]
Boc-aminooxy-amide-PEG4-propargyl | [Molecular Formula]
C18H32N2O8 | [MDL Number]
MFCD31715360 | [MOL File]
2253965-01-2.mol | [Molecular Weight]
404.46 |
| Hazard Information | Back Directory | [Uses]
Boc-aminooxy-amide-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Boc-aminooxy-amide-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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