| Identification | Back Directory | [Name]
MD2-TLR4-IN-1 | [CAS]
2249801-12-3 | [Synonyms]
MD2-TLR4-IN-1
Benzamide, 2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]- | [Molecular Formula]
C22H14Cl2N4O | [MDL Number]
MFCD32067977 | [MOL File]
2249801-12-3.mol | [Molecular Weight]
421.28 |
| Hazard Information | Back Directory | [Uses]
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1]. | [storage]
Store at -20°C | [References]
[1] Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469. DOI:10.1021/acs.jmedchem.9b00316 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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