| Identification | Back Directory | [Name]
RUBRATOXINA | [CAS]
22467-31-8 | [Synonyms]
RUBRATOXINA
10-[(3,6-Dihydro-6-oxo-2H-pyran-2-yl)hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-(1-hydroxyheptyl)-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione
9-[(3,6-Dihydro-6-oxo-2H-pyran-2-yl)hydroxymethyl]-3,4,5,8,9,10-hexahydro-1,5-dihydroxy-4-(1-hydroxyheptyl)-3-oxo-1H-cyclonona[c]furan-6,7-dicarboxylic anhydride
1H-Cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione, 10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-, (4S,5R,10R)-rel- | [Molecular Formula]
C26H32O11 | [MDL Number]
MFCD01735286 | [MOL File]
22467-31-8.mol | [Molecular Weight]
520.528 |
| Chemical Properties | Back Directory | [Melting point ]
210-214℃ (decomposition) | [storage temp. ]
Store at -20°C | [solubility ]
Acetonitrile: soluble; DMSO: soluble | [form ]
A powder | [color ]
White |
| Hazard Information | Back Directory | [Description]
Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A; IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 μM. It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts. | [Uses]
Rubratoxin A is a potent and selective competitive PP2A inhibitor. | [storage]
-20°C |
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| Company Name: |
Abcam
|
| Tel: |
+1 (877) 774-8286 |
| Website: |
www.abcam.com |
|