| Identification | Back Directory | [Name]
Thalidomide-O-amido-C4-NH2 hydrochloride | [CAS]
2245697-86-1 | [Synonyms]
Thalidomide-linker 3
-oxyacetamide-alkylC4-amine
Thalidomide-O-amido-C4-NH2 hydrochloride
N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride | [Molecular Formula]
C19H23ClN4O6 | [MDL Number]
MFCD31656719 | [MOL File]
2245697-86-1.mol | [Molecular Weight]
438.87 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2. |
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