| Identification | Back Directory | [Name]
IDH1 Inhibitor 2 | [CAS]
2244895-42-7 | [Synonyms]
H1 Inhibitor 2
IDH1 Inhibitor 2
IDH1 Inhibitor 2,IDH-1 Inhibitor 2 | [Molecular Formula]
C26H22N4O | [MDL Number]
MFCD32067987 | [MOL File]
2244895-42-7.mol | [Molecular Weight]
406.48 |
| Chemical Properties | Back Directory | [Boiling point ]
549.4±60.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
2.90±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
IDH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM[1].
IC50: 110 nM (IDH1)[1]. | [storage]
Store at -20°C | [References]
[1]. Jakob CG, et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018 Aug 9;61(15):6647-6657. |
|
|