| Identification | Back Directory | [Name]
Azido-PEG3-triethoxysilane | [CAS]
2243566-43-8 | [Synonyms]
Azido-PEG3-triethoxysilane
Azido-PEG3-amide-C3-triethoxysilane | [Molecular Formula]
C18H38N4O7Si | [MDL Number]
MFCD31693731 | [MOL File]
2243566-43-8.mol | [Molecular Weight]
450.61 |
| Hazard Information | Back Directory | [Description]
Azido-PEG3-triethoxysilane is a PEG linker containing azido and triethoxysilane moieties. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media. | [Uses]
Azido-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-amide-C3-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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