| Identification | Back Directory | [Name]
1,2-Ethanediamine, N1-[(3-bromophenyl)methyl]-N1-ethyl-, hydrochloride (1:2) | [CAS]
2243506-33-2 | [Synonyms]
NMDAR/TRPM4-IN-2
NMDAR-TRPM4 blocker C8 dihydrochloride
1,2-Ethanediamine, N1-[(3-bromophenyl)methyl]-N1-ethyl-, hydrochloride (1:2) | [Molecular Formula]
C11H18BrClN2 | [MOL File]
2243506-33-2.mol | [Molecular Weight]
293.63 |
| Hazard Information | Back Directory | [Biological Activity]
Compound 8 (C8) is a small molecule th at directly targets TRPM4 TwinF domain and blocks its interaction with GluN2A/GluN2B (NR2A/NR2B) I4 domain. C8 prevents NMDAR/TRPM4 interaction-dependent excitotoxicity (death protection EC50 = 2.1 μM 24 h post 10-min exposure of primary murine hippocampal neurons to 20 μM NMDA) without affectingand even enhancingNMDAR-mediated essential functions. C8 protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell (RGC) loss in mice in vivo (40 mg/kg i.p. at -16h-3h before0h3h24h after MCAO or 20 nmol NMDA/2.0 μL by intravitreal injection). |
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