| Identification | Back Directory | [Name]
4-Piperidinecarboxaldehyde, 1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | [CAS]
2241315-66-0 | [Synonyms]
BWA-522 intermediate-1
1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde
4-Piperidinecarboxaldehyde, 1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | [Molecular Formula]
C19H19N3O5 | [MOL File]
2241315-66-0.mol | [Molecular Weight]
369.37 |
| Chemical Properties | Back Directory | [Boiling point ]
660.2±55.0 °C(Predicted) | [density ]
1.474±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.83±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7[1]. | [IC 50]
Cereblon | [References]
[1] Arvinas Operations, et al. Indazole based compounds and associated methods of use. World Intellectual Property Organization, WO2021194879 A1 2021-09-30. |
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