| Identification | Back Directory | [Name]
N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE | [CAS]
223472-31-9 | [Synonyms]
ONO 4817
MMP Inhibitor V
N-[(1S,3S)-1-[(ETHOXYMETHOXY)METHYL]-4-(HYDROXYAMINO)-3-METHYL-4-OXOBUTYL]-4-PHENOXYBENZAMIDE | [Molecular Formula]
C22H28N2O6 | [MDL Number]
MFCD09971106 | [MOL File]
223472-31-9.mol | [Molecular Weight]
416.47 |
| Chemical Properties | Back Directory | [density ]
1.192±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
<20.82mg/ml in ethanol; <41.65mg/ml in DMSO | [form ]
solid | [pka]
9.55±0.40(Predicted) | [color ]
Off-white |
| Hazard Information | Back Directory | [Uses]
MMP Inhibitor V is a broad-spectrum inhibitor of matrix metalloproteinase (MMPs). | [Biological Activity]
Broad spectrum MMP inhibitor; K i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC 50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μ M. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma. | [References]
[1]. okamoto, y., et al., a matrix metalloproteinase inhibitor, ono-4817, suppresses the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbit. int heart j, 2007. 48(3): p. 369-78.
[2]. shiraga, m., et al., organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. cancer res, 2002. 62(20): p. 5967-73.
[3]. ro, y., et al., inhibitory effects of matrix metalloproteinase inhibitor ono-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats. nephrol dial transplant, 2007. 22(10): p. 2838-48. |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|