| Identification | Back Directory | [Name]
TOFISOPAM | [CAS]
22345-47-7 | [Synonyms]
SERIEL
Tosopam
EGYT 341
grandaxin
TOFISOPAM
tofizopam
Tofisopam, >=99%
TOFISOPAM 22345-47-7
7-CHLORO-1-METHYL-5-PHENYL-1,5-BENZODIAZEPINE-2,4-DIONE
-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-3-benzodiazepine
1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine
7,8-DIMETHOXY-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-4-METHYL-5H-2,3-BENZODIAZEPINE
1-(3,4-Dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-
1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine
1-[3,4-Bis(methyloxy)phenyl]-5-ethyl-4-methyl-7,8-bis(methyloxy)-5H-2,3-benzodiazepine
1-(3,4-DiMethoxyphenyl)-5-ethyl-7,8-diMethoxy-4-Methyl-5H-2,3-benzodiazepine (TofisopaM)
5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl- (8CI, 9CI)
EGYT 341, Seriel, 7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine
TofisopamQ: What is
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Tofisopam | [EINECS(EC#)]
244-922-3 | [Molecular Formula]
C22H26N2O4 | [MDL Number]
MFCD00823171 | [MOL File]
22345-47-7.mol | [Molecular Weight]
382.45 |
| Chemical Properties | Back Directory | [Melting point ]
155-159°C | [Boiling point ]
509.61°C (rough estimate) | [density ]
1.2098 (rough estimate) | [refractive index ]
1.6500 (estimate) | [solubility ]
DMSO: ~14 mg/mL
| [form ]
solid
| [pka]
7.29±0.40(Predicted) | [color ]
white
| [λmax]
310nm(MeOH)(lit.) | [Merck ]
14,9503 | [Stability:]
Hygroscopic |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-50 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
2
| [RTECS ]
DE9540000
| [HS Code ]
2933.99.8290 | [HazardClass ]
6.1(b) | [PackingGroup ]
III |
| Hazard Information | Back Directory | [Originator]
Grandaxine,Ozothine,France,1975 | [Uses]
Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant. | [Definition]
ChEBI: Tofisopam is an organic molecular entity. | [Manufacturing Process]
A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)-
benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11
mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the
reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of
5H-2,3-benzodiazepine derivative are separated from the residue as small,
white crystals. The melting point is 133°C to 136°C (after recrystallizing from
absolute ethanol, 136°C) | [Therapeutic Function]
Tranquilizer | [Biological Activity]
Studies have reported th at tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermorethe S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.''Ligand for the GABAA receptor benzodiazepine modulatory site. |
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