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Palmitoleic acid alkyne is a form of palmitoleic acid with an ω-terminal alkyne that can be used in click chemistry reactions.1 It has been used in the study of protein palmiteoylation. cis-Palmitoleic acid alkyne, but not trans-palmitoleic acid alkyne, labels wild-type, but not S209A mutant, Wnt3a in mouse fibroblast L-cells expressing Wnt3a. It also labels secreted wild-type Wnt3a in conditioned media. | [References]
1. Zheng, B., Jarugumilli, G.K., Chen, B., et al. Chemical probes to directly profile palmitoleoylation of proteins Chembiochem 17(21),2022-2027(2016). |
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