| Chemical Properties | Back Directory | [density ]
1.369±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 250 mg/mL (624.34 mM; Need ultrasonic) | [form ]
Solid | [pka]
7.26±0.25(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
WM-3835is a cell-permeable hydroxybenzenesulfonohydrazide compound th at acts as a potentselectiveAc-CoA competitive and reversible inhibitor of HBO1KAT6A and TIP60 acetyltransferases (IC50 = 0.0300.017 and 0.312 μMrespectively). WM-3835 is non-cytotoxicdose-dependentlyand rapidly decreases H3K14Ac levels (IC50 = 0.341 μM) and inhibits AML cells growth (IC50 = 0.297 μM in Molm13). Induces apoptosisdownregulates HOXA and IL-6 expression and up-regulates ALB secretion and delays hepatocyte and hMPC senescence. WM-1385 potently inhibits POS-1 xenograft growth in SCID mice (10 mg/kgi.p.). | [storage]
4°C, protect from light |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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