| Identification | Back Directory | [Name]
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[(5S)-5-C-phenyl-β-D-ribofuranosyl]- | [CAS]
2226515-75-7 | [Synonyms]
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[(5S)-5-C-phenyl-β-D-ribofuranosyl]- | [Molecular Formula]
C17H18N4O4 | [MOL File]
2226515-75-7.mol | [Molecular Weight]
342.35 |
| Chemical Properties | Back Directory | [Boiling point ]
688.9±55.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 68 mg/mL (198.63 mM);Ethanol: 68 mg/mL (198.63 mM) | [form ]
Solid | [pka]
12.46±0.70(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
LLY-284 is the diastereomer of LLY-283 with much less active. LLY-283 is a potent inhibitor of PRMT5. LLY-284 has the potential for the research of cancer diseases[1]. | [Biological Activity]
LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probeLLY-283please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website.
LLY-283the active probeis available from Sigma. To learn more about and purchase LLY-283click here.
To learn about other SGC chemical probes for epigenetic targetsvisit sigma.com/sgc | [References]
[1] Bonday ZQ, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med Chem Lett. 2018;9(7):612-617. DOI:10.1021/acsmedchemlett.8b00014 |
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| Company Name: |
Merck KGaA
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(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
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