| Identification | Back Directory | [Name]
mTOR inhibitor-2 | [CAS]
2219323-96-1 | [Synonyms]
mTOR inhibitor-2
mTOR inhibitor2,mTOR inhibitor 2
1-Piperidineacetonitrile, 4-[9-(6-amino-3-pyridinyl)-2-oxopyrazino[2,3-c]quinolin-1(2H)-yl]- | [Molecular Formula]
C23H21N7O | [MDL Number]
MFCD31813632 | [MOL File]
2219323-96-1.mol | [Molecular Weight]
411.46 |
| Hazard Information | Back Directory | [Uses]
mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates[1]. | [IC 50]
mTOR: 7 nM (IC50) | [References]
[1] Guo Q, et al. Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer. J Med Chem. 2018 Feb 8;61(3):881-904. DOI:10.1021/acs.jmedchem.7b01402 |
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