| Identification | Back Directory | [Name]
PDGFRα kinase inhibitor 1 | [CAS]
2209053-93-8 | [Synonyms]
PDGFRα kinase inhibitor 1
PDGFRα kinase inhibitor 1
3-Pyridinecarboxamide, N-[2-(dimethylamino)ethyl]-N-[[4-[[[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]methyl]- | [Molecular Formula]
C34H34N8O2 | [MDL Number]
MFCD31813650 | [MOL File]
2209053-93-8.mol | [Molecular Weight]
586.69 |
| Chemical Properties | Back Directory | [density ]
1.271±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 260 mg/mL (443.16 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.06±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].
PDGFRα kinase inhibitor 1 (CHMFL-PDGFR-159, Compound 15i) exhibits weak inhibition to DDR1 kinase (IC50: 2462±126 nM)[1]. | [References]
[1]. Wang Q, et al. Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384. |
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