| Identification | Back Directory | [Name]
AMINOPURVALANOL A | [CAS]
220792-57-4 | [Synonyms]
NG-97
AMINOPURVALANOL A
AMINOPURVALANOL A (APURV)
(2R)-2-[[6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
1-Butanol, 2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)- | [Molecular Formula]
C19H26ClN7O | [MDL Number]
MFCD06798384 | [MOL File]
220792-57-4.mol | [Molecular Weight]
403.91 |
| Chemical Properties | Back Directory | [Boiling point ]
639.0±65.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 100 mM in DMSO | [form ]
White to brownish solid. | [pka]
14.51±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Aminopurvalanol A is a reversible and ATP-competitive inhibitor of Cdks. | [Definition]
ChEBI: Aminopurvalanol is a purvalanol and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor. | [Biological Activity]
Cell-permeable cyclin-dependent kinase inhibitor. IC 50 values are 0.033, 0.033, 0.028 and 0.020 μ M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC 50 = 12.0 μ M) and ERK2 (IC 50 = 3.1 μ M) and is 3000-fold selective over a range of other protein kinases (IC 50 > 100 μ M). Arrests cell cycle at G 2 /M boundary (IC 50 = 1.25 μ M), and induces apoptosis at concentrations > 10 μ M. | [Enzyme inhibitor]
This cell-permeable purvalanol derivative (FW = 403.92 g/mol), also named (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)- 9H-purin-2-yl]amino]-3-methyl-1-butanol, targets cdk1/cyclin B (IC50 = 0.033 μM), cdk2/cyclin A (IC50 = 0.033 μM), cdk2/cyclin E (IC50 = 0.028 μM), and cdk5/p35 (IC50 = 0.020 μM). It also inhibits ERK1 (IC50 = 12 μM) and ERK2 (IC50 = 3.1 μM), with 3000-times greater selectivity versus a range of other protein kinases (IC50 > 100 μM). Aminopurvalanol A arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM. | [storage]
Store at +4°C |
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