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CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia.1 In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 μM) has been used to detect hypoxia in A549 human lung carcinoma cells. | [References]
1. More, K.N., Lim, T.-H., Kim, S.-Y., et al. Characteristics of new bioreductive fluorescent probes based on the xanthene fluorophore: Detection of nitroreductase and imaging of hypoxic cells Dyes Pigm. 151,245-253(2018). |
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