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ChemicalBook--->CAS DataBase List--->2196203-96-8

2196203-96-8

2196203-96-8 Structure

2196203-96-8 Structure
IdentificationBack Directory
[Name]

TH34
[CAS]

2196203-96-8
[Synonyms]

TH34
CS-2858
TH34;TH 34
[Molecular Formula]

C15H16N2O2
[MDL Number]

MFCD31812450
[MOL File]

2196203-96-8.mol
[Molecular Weight]

256.3
Chemical PropertiesBack Directory
[density ]

1.236±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[solubility ]

DMSO : 150 mg/mL (585.25 mM)
[form ]

Solid
[pka]

9.04±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

TH34 is an HDAC6/8/10 inhibitor with IC50 values of 4.6 μM, 1.9 μM and 7.7 μM, respectively, showing high selectivity compared with HDAC1/2/3.
[in vitro]

TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells.

[target]

HDAC6

4.6 μM (IC 50 )

HDAC8

1.9 μM (IC 50 )

HDAC10

7.7 μM (IC 50 )

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