| Identification | Back Directory | [Name]
DIACETYL BENZOYL LATHYROL | [CAS]
218916-52-0 | [Synonyms]
Eupho
Phytoclear EL-1
Euphorbia factor L3
Euphporbia factor L3
DIACETYL BENZOYL LATHYROL
Lathyrol diacetate benzoate
5,15-Diacetyl-3-benzoyllathyrol
Euphorbia factor L3 218916-52-0
Lathyrol-3,15-diacetate-5-benzoate
(1aR,2E,4aR,6S,7S,7aR,8R,11aS)-4a,8-Bis(acetyloxy)-7-(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-4H-cyclopenta[a]cyclopropa[f]cycloundecen-4-one
4H-Cyclopenta[a]cyclopropa[f]cycloundecen-4-one, 4a,8-bis(acetyloxy)-7-(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-, (1aR,2E,4aR,6S,7S,7aR,8R,11aS)-
4H-Cyclopenta[a]cyclopropa[f]cycloundecen-4-one,4a,8-bis(acetyloxy)-7-(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-,(1aR,2E,4aR,6S,7S,7aR,8R,11aS)-rel-(+)- | [Molecular Formula]
C31H38O7 | [MDL Number]
MFCD09752801 | [MOL File]
218916-52-0.mol | [Molecular Weight]
522.634 |
| Chemical Properties | Back Directory | [Boiling point ]
595.5±50.0 °C(Predicted) | [density ]
1.19 | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [color ]
White to off-white |
| Questions And Answer | Back Directory | [Cytotoxicity]
EFL3 of lathyrane diterpenoids showed potent cytotoxicity to A549 cells. Furthermore, EFL3 induced apoptosis of A549 cells through mitochondrial pathway with involvement of loss of ΔΨm, release of cytochrome c.
The cytotoxicity of EFL3 was determined by an MTT assay to evaluate its antitumor activity. The results showed that EFL3 inhibited cell proliferation in a concentration-dependent manner in A549 cells after 72 h treatment. The IC50 of EFL3 for A549 cells was 34.04 ± 3.99 μM. The data suggested that EFL3 exhibited potent cytotoxicity towards these cells.
The results showed that EFL3 showed more potent cytotoxicity to A549 cellsMolecules 2011, 16 3225 than EFL1 (P < 0.01).
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| Hazard Information | Back Directory | [Uses]
Lathyrol-3,15-diacetate-5-benzoate could induce apoptosis in lung cancer A549 cells through the mitochondrial pathway including the loss of mitochondrial potential and release of cytochrome c. | [Definition]
ChEBI: Diacetyl benzoyl lathyrol is a diterpenoid. |
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