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ChemicalBook--->CAS DataBase List--->2183440-37-9

2183440-37-9

2183440-37-9 Structure

2183440-37-9 Structure
IdentificationBack Directory
[Name]

TCO-PEG9-maleimide
[CAS]

2183440-37-9
[Synonyms]

TCO-PEG9-maleimide
5,8,11,14,17,20,23,26,29-Nonaoxa-2,32-diazapentatriacontanoic acid, 35-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-33-oxo-, 4-cycloocten-1-yl ester
[Molecular Formula]

C36H61N3O14
[MDL Number]

MFCD31580141
[MOL File]

2183440-37-9.mol
[Molecular Weight]

759.88
Chemical PropertiesBack Directory
[solubility ]

Soluble in DMSO, DMF, DCM
[form ]

Oil
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

TCO-PEG4-maleimide is a bifunctional crosslinker containing a TCO moiety and a maleimide group. The maleimide group can react with thiol groups to form a stable thioester bond between pH 6.5 to 7.5. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. TCO can be used to label antibodies, proteins and othe rtetrazine-containing macromolecules.
[Uses]

TCO-PEG9-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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