Identification | Back Directory | [Name]
TCO-PEG9-maleimide | [CAS]
2183440-37-9 | [Synonyms]
TCO-PEG9-maleimide 5,8,11,14,17,20,23,26,29-Nonaoxa-2,32-diazapentatriacontanoic acid, 35-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-33-oxo-, 4-cycloocten-1-yl ester | [Molecular Formula]
C36H61N3O14 | [MDL Number]
MFCD31580141 | [MOL File]
2183440-37-9.mol | [Molecular Weight]
759.88 |
Hazard Information | Back Directory | [Description]
TCO-PEG4-maleimide is a bifunctional crosslinker containing a TCO moiety and a maleimide group. The maleimide group can react with thiol groups to form a stable thioester bond between pH 6.5 to 7.5. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. TCO can be used to label antibodies, proteins and othe rtetrazine-containing macromolecules. | [Uses]
TCO-PEG9-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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