| Identification | Back Directory | [Name]
SOD1-Derlin-1 inhibitor 56-59 | [CAS]
2170170-27-9 | [Synonyms]
SOD1-Derlin-1 inhibitor-2
SOD1-Derlin-1 inhibitor 56-59
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-phenyl-N-2-propen-1-yl-6-(3-pyridinyl)- | [Molecular Formula]
C22H18N4OS | [MOL File]
2170170-27-9.mol | [Molecular Weight]
386.47 |
| Chemical Properties | Back Directory | [Boiling point ]
644.3±55.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3?+-.0.12(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. | [in vivo]
SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3?mM, flow rate 0.15?μL/h) ameliorates ALS pathology in ALS model mice[1]. | Animal Model: | ALS model C57BL/6 mice[1] | | Dosage: | 3?mM, flow rate 0.15?μL/h | | Administration: | intracerebroventrical injection | | Result: | Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement). |
| [References]
[1] Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668. DOI:10.1038/s41467-018-05127-2 |
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