| Identification | Back Directory | [Name]
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P | [CAS]
215923-54-9 | [Synonyms]
GR 87
CX-546
BDP 17
BDP-17,CX546,GR87
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine
(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone
Methanone,(2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinyl-
(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)Methanone
(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylMethanone CX 546 | [Molecular Formula]
C14H17NO3 | [MDL Number]
MFCD01860868 | [MOL File]
215923-54-9.mol | [Molecular Weight]
247.29 |
| Chemical Properties | Back Directory | [Melting point ]
71-73°C | [Boiling point ]
422.8±44.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
solid | [pka]
-1.08±0.20(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
It is one of a series of AMPA modulators
matergic AMPA receptors. | [General Description]
CX546, a benzoylpiperidine derivative ampakine is an analog of CX516. | [Biological Activity]
AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats. | [Biochem/physiol Actions]
CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression. | [storage]
Store at +4°C |
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