| Identification | Back Directory | [Name]
BPK-29 | [CAS]
2143467-62-1 | [Synonyms]
BPK-29
BPK-29 >=98% (HPLC)
Acetamide, 2-chloro-N-[hexahydro-1-[4-(4-morpholinyl)benzoyl]-1H-azepin-4-yl]-N-(phenylmethyl)- | [Molecular Formula]
C26H32ClN3O3 | [MDL Number]
MFCD32062800 | [MOL File]
2143467-62-1.mol | [Molecular Weight]
470 |
| Chemical Properties | Back Directory | [Boiling point ]
686.6±55.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.88±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
BPK-29 is a potent and selective NR0B1 ligand th at covalently binds to NR0B1 Cys 274. BPK-29 inhibits the NR0B1-SNW1 interaction. It inhibits the anchorage-independent growth of KEAP1-mutant cancer cells.''BPK-29 is a small molecule inhibitor th at blocks the nuclear factor erythroid 2–related factor 2 (NRF2) pathway. It targets the cysteine 274 residue in the nuclear receptor subfamily 0 group B member 1 (NR0B1) and disrupts protein-protein interactions in non-small-cell lung cancer (NSCLC) cell proteomes. | [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|