| Chemical Properties | Back Directory | [Boiling point ]
550.0±50.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
13.82±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
Orally availablepotent and selective pan-second bromodomain (BD2) inhibitor th at effectively inhibits LPS-induced MCP-1 release in human whole blood.
GSK973 is an orally availablepotent and selective pan-second bromodomain (BD2) inhibitor (BD2/BD1 pIC50 = 7.5/4.4/BRD27.8/4.5/BRD37.8/4.6/BRD47.4/4.5/BRDT) th at effectively inhibits LPS-induced MCP-1 release in human whole blood (pIC50 = 7.3; IC50 = 50 nM). |
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