| Identification | Back Directory | [Name]
UPF 648 | [CAS]
213400-34-1 | [Synonyms]
DBCC
UPF648
UPF 648
(1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid
Cyclopropanecarboxylic acid, 2-(3,4-dichlorobenzoyl)-, (1S,2S)- | [Molecular Formula]
C11H8Cl2O3 | [MOL File]
213400-34-1.mol | [Molecular Weight]
259.09 |
| Chemical Properties | Back Directory | [Boiling point ]
461.3±45.0 °C(Predicted) | [density ]
1.556±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
3.89±0.11(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UPF-648 is a kynurenine 3-monooxygenase (KMO) inhibitor. KMO is a key enzyme that is part of the kynurenine pathway, which is a metabolic pathway that utilizes tryptophan to produce nicotinamide adenine dinucleotide (NAD+). KMO is a potential therapeutic target for treating neurodegenerative and psychiatric disorders. | [Biological Activity]
UPF-648 is a potentactive site-targeting kynurenine 3-monooxygenase (KMO; kynurenine 3-hydroxylase) inhibitor (IC50 = 20 nM) th at prevents productive binding of the substrate L-kynurenine by perturbing the local active-site structure. UPF-648 protects against neurodegeneration in a murine (30 mg/kgi.p.) and a Drosophila (100 μM in maize media) model of Huntingtonμs disease by shifting kynurenine pathway metabolism towards enhanced neuroprotective kynurenic acid (KYNA) formation and away from the free radicals generator 3-hydroxykynurenine (3-HK) and the excitotoxic quinolinic acid (QUIN). | [storage]
Store at +4°C |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|