| Identification | Back Directory | [Name]
Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl- | [CAS]
212391-58-7 | [Synonyms]
PP58
Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl- | [Molecular Formula]
C22H19Cl2N5O2 | [MOL File]
212391-58-7.mol | [Molecular Weight]
456.32 |
| Chemical Properties | Back Directory | [Boiling point ]
663.7±65.0 °C(Predicted) | [density ]
1.426±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.57±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values. | [in vivo]
PP58 can exhibit some degree of selectivity at low nanomolar concentrations in vivo[1]. | [IC 50]
PDGFR | [storage]
Store at -20°C | [References]
[1] Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3(12):1181-93. DOI:10.1074/mcp.M400124-MCP200
[2] Blencke S, et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004 May;11(5):691-701. DOI:10.1016/j.chembiol.2004.02.029 |
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cjbscvictory
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