| Chemical Properties | Back Directory | [Boiling point ]
947.1±65.0 °C(Predicted) | [density ]
1.390±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 104 mg/mL (169.47 mM) | [form ]
Solid | [pka]
10.70±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CDK9-PROTAC can be used as a selective CDK9 degrader. | [Biological Activity]
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader. | [in vitro]
PROTAC CDK9 Degrader-1 (Compound 3; 2.5-20 μM; 6 hours) degrades CDK9 in a dose dependent manner in HCT116 cells. Western Blot Analysis | Cell Line: | HCT116 cells | | Concentration: | 2.5, 5, 10, and 20μM | | Incubation Time: | 6 hours | | Result: | Degraded CDK9 in a dose dependent manner . | | [target]
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