| Identification | Back Directory | [Name]
3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine | [CAS]
2117405-13-5 | [Synonyms]
SEN177
SEN 177
SEN177;SEN 177
3-(6-fluoropyridin-3-yl)-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]pyridine | [EINECS(EC#)]
821-054-9 | [Molecular Formula]
C18H19FN6 | [MDL Number]
MFCD30343871 | [MOL File]
2117405-13-5.mol | [Molecular Weight]
338.38 |
| Chemical Properties | Back Directory | [Boiling point ]
581.3±60.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO:36.0(Max Conc. mg/mL);106.3(Max Conc. mM) | [form ]
Solid | [pka]
6.72±0.31(Predicted) | [color ]
Brown to gray |
| Hazard Information | Back Directory | [Definition]
ChEBI: SEN177 is a member of bipyridines. | [Biological Activity]
SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregatesbut also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism th at requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cellsprimary neurons and in a Drosophila model. | [storage]
Store at -20°C |
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