| Identification | Back Directory | [Name]
BMY 7378 DIHYDROCHLORIDE | [CAS]
21102-95-4 | [Synonyms]
CS-1419
BMY7378 HCl
BMY73782HCl
BMY 7378, >=98%
BMY7378;BMY-7378
BMY 7378 2hydrochloride
BMY 7378 DIHYDROCHLORIDE
8-(2-(4-(2-Methoxyphenyl)
BMY 7378 DIHYDROCHLORIDE;BMY 7378
BMY 7378 DIHYDROCHLORIDE USP/EP/BP
-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
BMY 7378 DIHYDROCHLORIDE >98% PARTIAL 5- HT1A SEROTO
1-cyclopentanediacetimide,n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-d
n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimided
N-(2-(4-(o-Methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimide dihydrochloride
8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
8-[2-[4-(METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE DIHYDROCHLORIDE
8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4.5)DECANE-7,9-DIONE DIHYDROCHLORIDE
8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
1,1-Cyclopentanediacetimide, N-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-, dihydrochloride
8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2)
BMY 7378 DIHYDROCHLORIDE;8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4,5)DECANE-7,9-DIONE DIHYDROCHLORIDE
8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride BMY7378 | [Molecular Formula]
C22H32ClN3O3 | [MDL Number]
MFCD00153771 | [MOL File]
21102-95-4.mol | [Molecular Weight]
421.97 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
H2O: soluble
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist. | [Biological Activity]
5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ . | [Biochem/physiol Actions]
BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist. | [storage]
Room temperature | [References]
1. yocca fd, hyslop dk, smith dw et al. bmy 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-ht1a receptor in rat and guinea pig hippocampal membranes. eur j pharmacol. 1987 jun 4;137(2-3):293-4.2. zemlan fp, zieleniewski-murphy a, maureen murphy r et al bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. neurochem int. 1990;16(4):515-22.3. goetz as, king hk, ward sd et al. bmy 7378 is a selective antagonist of the d subtype of alpha 1-adrenoceptors. eur j pharmacol. 1995 jan 16;272(2-3):r5-6.4. cleary l, murad k, bexis s et al. the alpha (1d)-adrenoceptor antagonist bmy 7378 is also an alpha (2c)-adrenoceptor antagonist. auton autacoid pharmacol. 2005 oct;25(4):135-41.5. sharp t, backus li, hjorth s et al. further investigation of the in vivo pharmacological properties of the putative 5-ht1a antagonist, bmy 7378. eur j pharmacol. 1990 feb 13;176(3):331-40. |
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