| Identification | Back Directory | [Name]
N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride | [CAS]
1803003-68-0 | [Synonyms]
PM-0025
RN 9893
RN9893 HCl
RN-9893 HCl
RN 9893 HCl
RN-9893 >=98% (HPLC)
RN 9893 hydrochloride
Benzamide, N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)-
N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride | [Molecular Formula]
C21H23F3N4O5S | [MDL Number]
MFCD29917838 | [MOL File]
1803003-68-0.mol | [Molecular Weight]
500.49 |
| Chemical Properties | Back Directory | [density ]
1.421±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 25mg/mL, clear | [form ]
Solid | [pka]
11.01±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RN 9893 Hydrochloride is a selective TRPV4 inhibitor. | [Biological Activity]
RN-9893 is a potent and selective antagonist of the Transient Receptor Potential ion channel TRPV4. RN-9893 has IC50 values of 420 nM660 nMand 320 nM for humanr at and mouse TRPV4 receptorsrespectively. RN-9893 shows excellent selectivity over related TRP receptors with no inhibition of TRPV1 at a concentration of 10 μMan IC50 >30 μM against TRPV3an IC50 of approximately 30 μM against TRPM8and also good selectivity using 54 binding assays against common biological targets. |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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www.sangon.com |
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