| Identification | Back Directory | [Name]
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole | [CAS]
210690-85-0 | [Synonyms]
4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2,6,10-triMethyl-1,5-undecadien-1-yl]-2-Methyl-thiazole
4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole | [Molecular Formula]
C30H57NO2SSi2 | [MDL Number]
MFCD04039436 | [MOL File]
210690-85-0.mol | [Molecular Weight]
552.015 |
| Chemical Properties | Back Directory | [Appearance]
Colourless Oil | [Boiling point ]
550.1±50.0 °C(Predicted) | [density ]
0.939±0.06 g/cm3(Predicted) | [solubility ]
Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene | [form ]
Oil | [pka]
2.73±0.10(Predicted) | [color ]
Colourless |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless Oil | [Uses]
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Carbosynth
|
| Tel: |
+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
| Company Name: |
Medical Isotopes
|
| Tel: |
1-(603) 635-1722 |
| Website: |
www.medicalisotopes.com |
|