| Chemical Properties | Back Directory | [Boiling point ]
822.4±65.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.86±0.20(Predicted) | [color ]
Brown to dark brown |
| Hazard Information | Back Directory | [Description]
CM03 is a potent inhibitor of cell growth in PDAC cell lines, and has anticancer activity in PDAC models, with a superior profile compared to gemcitabine, a commonly used therapy. Whole-transcriptome RNA-seq methodology has been used to analyze the effects of this quadruplexbinding small molecule on global gene expression. This has revealed the down-regulation of a large number of genes, rich in putative quadruplex elements and involved in essential pathways of PDAC survival, metastasis, and drug resistance. The changes produced by CM03 represent a global response to the complexity of human PDAC and may be applicable to other currently hard-to-treat cancers. |
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