| Identification | Back Directory | [Name]
A-395 | [CAS]
2089148-72-9 | [Synonyms]
A-395
A-395,Histone Methyltransferase,A395,A 395,Inhibitor,inhibit
3-Pyrrolidinamine, 1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-[4-(methylsulfonyl)-1-piperazinyl]phenyl]-, (3R,4S)- | [Molecular Formula]
C26H35FN4O2S | [MOL File]
2089148-72-9.mol | [Molecular Weight]
486.65 |
| Chemical Properties | Back Directory | [Boiling point ]
612.2±65.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (205.49 mM) | [form ]
Solid | [pka]
8.49±0.40(Predicted) | [color ]
White to yellow | [Water Solubility ]
H2O: 10mg/mL, clear |
| Hazard Information | Back Directory | [Biological Activity]
A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development)an essential component of Polycomb repressive complex 2 (PRC2)involved in transcriptional repression through methylation of histone H3K27. A-395 has been found to bind to EED in vitro with a Ki value of 0.4 nMinhibit the PRC2 complex with an IC50 value 34 nM for methylation of H3K27and have >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In RD rhabdoid tumor cell line A-395 inhibited the PRC2 complex with an IC50 value of 90 nMinhibiting the formation of H3K27me3. For characterization details of A-395please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.
A-395N is the negative control for the active enantiomerA-395. A-395N is available from Sigma. To learn more about and purchase A-395N | [storage]
Store at -20°C |
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| Company Name: |
ChemeGen 中國
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| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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