| Identification | Back Directory | [Name]
LYN-1604 | [CAS]
2088939-99-3 | [Synonyms]
CS-2610
CS-2635
LYN-1604
LYN-1604 Hcl
LYN-1604 2HCl
LYN1604;LYN 1604
LYN-1604;LYN 1604;LYN1604
Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]- | [Molecular Formula]
C33H43Cl2N3O2 | [MDL Number]
MFCD31619235 | [MOL File]
2088939-99-3.mol | [Molecular Weight]
584.62 |
| Chemical Properties | Back Directory | [Boiling point ]
670.9±55.0 °C(Predicted) | [density ]
1.168±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid | [pka]
8.03±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
LYN-1604 is an activator of unc-51-like kinase 1 (ULK1; EC50 = 18.94 nM). It increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 triple-negative breast cancer (TNBC) cells in a concentration-dependent manner, indicating an increase in autophagy. It also increases the cleavage of the pro-apoptotic protein caspase-3. LYN-1604 decreases the viability of MDA-MB-231 cells in vitro (IC50 = 1.66 μM), an effect that can be reversed by the autophagy inhibitor 3-methyladenine (3-MA; ). LYN-1604 (25, 50, and 100 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. |
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