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ChemicalBook--->CAS DataBase List--->2088453-21-6

2088453-21-6

2088453-21-6 Structure

2088453-21-6 Structure
IdentificationBack Directory
[Name]

OATD-01
[CAS]

2088453-21-6
[Synonyms]

OATD-01
inhibit,CHIT1,OATD-01,chitinase,antifibrotic,IPF,pulmonary fibrosis,OATD01,OATD 01,Inhibitor
1H-1,2,4-Triazol-3-amine, 5-[4-[(2S,5S)-5-[(4-chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-
[Molecular Formula]

C19H27ClN6O
[MDL Number]

MFCD33023453
[MOL File]

2088453-21-6.mol
[Molecular Weight]

390.91
Chemical PropertiesBack Directory
[Boiling point ]

586.4±60.0 °C(Predicted)
[density ]

1.297±0.06 g/cm3(Predicted)
[solubility ]

DMSO:100.0(Max Conc. mg/mL);255.81(Max Conc. mM)
[form ]

A solid
[pka]

12.86±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1,IC50=23 nM). OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research[1].
[in vivo]

OATD-01 (oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days) shows significant antifibrotic efficacy in an animal model of Bleomycin (HY-108345)-induced pulmonary fibrosis. It reduces the degree of lung fibrosis in a dose-dependent manner, ultimately achieving comparable therapeutic efficacy to reference treatment with Nintedanib (HY-50904) in this animal model[1].

Animal Model:Female BALB/c mice[1]
Dosage:30 mg/kg, 100 mg/kg
Administration:Oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days
Result:Reduced the degree of lung fibrosis in vivo[1]
[References]

[1] Robert Koralewski, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63(24):15527-15540. DOI:10.1021/acs.jmedchem.0c01179
Spectrum DetailBack Directory
[Spectrum Detail]

OATD-01(2088453-21-6)1HNMR
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